Historically, primary care has been the first line of treatment for those who experience co-occurring mental and chronic health conditions. Often termed “medically complex”, these patients have unique healthcare needs that require providers to operate above and beyond their typical practice. Unsurprisingly, the COVID-19 Pandemic has added a new layer of complexity, leading many providers to continuously evolve in their approach to treatment. In this Community Conversation, we explored these practices for supporting medically complex patients during the COVID-19 Pandemic.